Human elastin is mainly synthesized from late embryonic to early neonatal period, and almost no new elastin is produced during adulthood. Elastic fibers undergo different changes during endogenous aging and photoaging.
1. Gender and different body parts
As early as 1990, some scholars tested 33 volunteers to study the elasticity of the skin in 11 parts of the human body.
Indicates that skin elasticity is significantly different between different parts; while there is basically no significant difference between different genders
Skin elasticity gradually decreases with age.
2. Age
With increasing age, endogenous aging skin is less elastic and pliable than younger skin, and the elastic fiber network breaks and declines, manifesting as skin flattening and fine wrinkles; in endogenous aging, not only fibrous Degradation of ECM components, but also the loss of some oligosaccharide fragments. LTBP-2, LTBP-3, and LOXL-1 were all up-regulated, and LTBP-2 and LOXL-1 play important roles in controlling and maintaining fibrin deposition, assembly, and structure by binding fibulin-5. Perturbations associated with factor expression emerge as mechanisms to increase endogenous aging.
3. Environmental factors
The damage of environmental factors to the skin, mainly photoaging, air pollution and other factors has gradually been paid attention to, but the research results are not systematic.
Photoaging skin is characterized by both catabolic and anabolic remodeling and transformation. The skin appears rough and deeply wrinkled due not only to the loss of fibrillin-rich microfibrils at the epidermis-dermal junction, elastin degeneration, but more importantly, to the deposition of chaotic elastin substances in the deep dermis, the function of elastin affected.
The structural damage to the elastic fibers of the skin is irreversible before the age of 18, and UV protection is important during the growth phase. There may be two mechanisms of elastic fiber sunlight: elastic fibers are degraded by elastase secreted by surrounding cells or irradiated by UV, and elastic fibers are bent during the synthesis process; fibroblasts have the effect of promoting elastic fibers to maintain linearity. The effect becomes weaker, resulting in bending.—— Yinmou Dong<Skin Epiphysiology> Chemical Industry Press，158-160
The change process of skin elasticity may not be obvious enough to the naked eye, and we can use professional skin diagnostic analyzer observe and even predict the future change trend of the skin.
For example, ISEMECO or Resur Skin Analyzer, with the help of professional lighting and high-definition camera to read skin information, combined with AI analysis algorithm, can observe the details and prediction of skin changes .
Post time: Nov-11-2022
