Hormone declines with age, including estrogen, testosterone, dehydroepiandrosterone sulfate, and growth hormone. The effects of hormones on the skin are manifold, including increased collagen content, increased skin thickness, and improved skin hydration . Among them, the influence of estrogen is more obvious, but the mechanism of its influence on cells is still poorly understood. The effect of estrogen on the skin is mainly realized through the keratinocytes of the epidermis, fibroblasts and melanocytes of the dermis, as well as hair follicle cells and sebaceous glands. When women’s ability to produce estrogen decreases, the skin aging process accelerates. Deficiency of the hormone estradiol reduces the activity of the basal layer of the epidermis and reduces the synthesis of collagen and elastic fibers, all of which are essential for maintaining good skin elasticity. The decline of postmenopausal estrogen levels not only leads to a decrease in skin collagen content, but also the metabolism of dermal cells is affected by postmenopausal low estrogen levels, and these changes can be quickly reversed by topical application of estrogen. Experiments have confirmed that female topical estrogen can increase collagen, maintain skin thickness, and maintain skin moisture and the barrier function of the stratum corneum by increasing acidic glycosaminoglycans and hyaluronic acid, so that the skin maintains good elasticity. It can be seen that the decline of the body’s endocrine system function is also one of the important influencing factors of the skin aging mechanism.
Reduced secretion from the pituitary, adrenal, and gonads contributes to the characteristic changes in body and skin phenotype and behavioral patterns associated with aging. Serum levels of 17β-estradiol, dehydroepiandrosterone, progesterone, growth hormone, and their downstream hormone insulin growth factor (IGF)-I decrease with age. However, the levels of growth hormone and IGF-I in male serum decreased significantly, and the decline of hormone levels in some populations may occur at an older stage. Hormones can affect skin form and function, skin permeability, healing, cortical lipogenesis, and skin metabolism. Estrogen replacement therapy can prevent menopause and endogenous skin aging.
——”Skin Epiphysiology” Yinmao Dong, Laiji Ma, Chemical Industry Press
Therefore, as we grow older, our attention to skin conditions should gradually increase. We can use some professional skin analysis equipment to observe and predict the stage of the skin, predict skin problems early, and actively deal with them.
Post time: Jan-05-2023
